Screening of Phyllanthus Niruri Leaf Phytoconstituents by Insilico and in vivo Methods for Anticonvulsant Activity - Abstract
Background: In the present study, we evaluated anticonvulsant activity of Phyllanthus niruri leaves powder by Insilico and in vivo methods. A molecular docking investigation of leaf components with certain proteins associated with diseases was carried out using Schrodinger Maestro (v13.0) software. Materials and Methods: Higher scores were also seen in the molecular docking data when compared to typical medications that are easily accessible. Invivo activity was carried out by 1 method i.e., Maximal Electroshock-Induced Convulsions. Results and Discussion: The animals were then treated with 100mg/kg body weight i.p of Estradiol syrup formulation. According to the findings of the acute toxicity trials, estradiol was not harmful in nature on 300mg/kg concentration by showing 80% cell viability. The number of viable animals tends to decrease as the concentration of Estradiol increases. Conclusion: Phyllanthus niruri leaves powder exhibited anticonvulsant activity in Maximal Electroshock Induced convulsion method.