Introduction: Asians have lower mean BMI than that of non-Asian populations. There is a lack of sufficient data from Asian countries with WHO consultation to describe either there is an association of BMI with body fat or to CAD. The aim of the study was to correlate the BMI and coronary artery measurements to find out any association between them to be a precursor to CAD. The objective was focused to find the possible association of body mass index (BMI) with normal coronary vessel dimensions. Materials and Methods: Four thousand angiograms from patients of Indian origin were studied prospectively after procuring the sanction for the same from the ethical committee of the pre-selected hospitals from four states of South India. Patient’s anthropometric measurements were done using the fore mentioned relevant equipments. BMI and BSA were calculated. Informed consents were obtained. Post CABG, post PCI patients and patient being diabetic for ?5 years were excluded from the study. Results: Among total sample population, normal coronary arteries were seen in 933 (23.3%), cases and 3,067 (76.7%), had diseased coronary arteries. The average weight was 63.19 ± 5.09 kg (range 90.00– 37.00 kg), height was 168.15 ± 4.60cm (range 190.00–135.00 cm). An overall significant negative correlation was observed among 933 cases of normal samples of indexed coronary artery measurements with BMI. Conclusion: The present study concludes that with increase in BMI, there was a relative decrease in coronary artery diameter. The risk of CAD and associated multimorbidity is directly proportional to BMI.