Migraine is a Multifaceted Condition That is More Than Just a Headache: A Review - Abstract
Background: Migraine is a complex and common neuro-vascular disorder with a distinctive periodicity and is described by a reduced level of neuronal hyper-excitability. It is imperative to comprehend the complexity of the disorder from the standpoint of pathological mechanisms, genetic variable associations that contribute to disease severity, and a debatable phenotype i.e., inflammation which might contribute to the chronification of the condition, migraine as a channelopathy, and constellations network of co-morbidities. Aim: In the present review, we aim to better understand the complexity of migraine by consolidating the provided data. Material & method: Online repositories including PubMed, Web of Science, and Google Scholar were used for the literature survey and relevant articles were utilized to comprehend the complexity of migraines for better understanding. Result: Migraine is a complex neurological disorder featuring a heap of candidate gene alterations that predispose by altering the function of channels in the brain, hindering the process of inflammatory homeostasis, microglial activation, and complex interaction with different diseases.
Conclusion: In conclusion, featured with a wide abnormal pattern of phenotype enlightened the complicated nature of migraine, and it can’t be said that migraine is not just a headache but more than it.