Injury to the tissue activates the proteins of the coagulation cascade which is vital to stop blood loss from the site of injury followed by the restoration of normal tissue by clearing dead tissue debris. Platelets, underlying epithelial cells, coagulation factors, fibrinolytic systems, and blood vessels maintain the coagulation system. Bleeding disorders are caused by any slight imbalance of any of the processes in the cascade and can lead to complications such as hemorrhage or thrombosis. The lack of coagulation factors resulting in excessive blood loss. Currently, bypass agents, replacement, and recombinant factors are used to treat the bleeding disorders which is not recommended for a longer period due to the production of inhibitory antibodies and anaphylactic reactions. Plant-based treatment is gaining importance for its safety and efficacy. Plant latex proteases are one of the major sources of therapeutics that are used for treating various conditions. Many proteases are characterized by their pro-coagulant activity and stop bleeding due to the presence of thrombin-like enzymes. Thrombin-like latex proteases aid the clotting of factor VIII-deficient plasma. Also, they play a major role in clotting by enhancing platelet aggregation by activating protease-activated receptors 1 and 4. The action of latex proteases is of the broad spectrum. It is essential to check the specific targets and assess their complete pharmaco-characterization to make them possibly better molecules with fewer side effects and enhanced efficiency. This can be an inexpensive and better alternative strategy to treat external wounds in bleeding disorders than the existing strategies.