Brooke-Spiegler Syndrome (BSS) is a rare autosomal dominant genodermatosis with variable penetrance, which is characterized by maintaining a progressive association of generally benign cutaneous adnexal neoformations among themselves. cylindromas, spiroadenomas and trichoepitheliomas. Other less frequently involved are trichoblastomas, follicular cysts, and organoid nevi. There are multiple phenotypic variants of SBS, which share the same genotypic origin; due to the overlap of the different lesions between them at a clinical, pathological, and genetic level, of which the present clinical case maintains a variant form that is rare in an association of multiple giant spiroadenocylindromas in a geriatric patient [1-11].