Fusarium infections are rare opportunistic mycosis caused by Fusarium spp. Its clinical presentation depends on the immunological status of the host; those immunosuppressed hemato-oncological diseases can present invasive fungal. Diagnosis is through Skin or blood culture and it is treated with antifungal medication such as amphotericin B and voriconazole alone or in combination. We present the case of a neutropenic 55-year-old woman undergoing chemotherapy treatment for B-cell acute lymphoblastic leukemia who presented disseminated skin lesions which included macules, papules and violaceous nodules, with a central necrotic crust. A skin biopsy, KOH exam, tissue and blood cultures were carried out where Fusarium spp. were identified. Treatment with amphotericin b combined with voriconazole was initiated, with good results and complete disappearance of the lesions