Recently, the uses of intralesional cryosurgery (ILC) have been rapidly expanding in the f ield of dermatology and oncology. Thus far, ILC has been effectively used to treat keloids, hidradenitis suppurativa (HS), basal cell carcinomas (BCCs), and cutaneous metastases. These conditions can be difficult to treat so it is significant to have an alternative, effective treatment option available. ILC has several advantages over other treatment options for these conditions such as the method’s simplicity, cost-effectiveness, and lack of side effects, pain, and complications. This manuscript reviews data concerning the use of ILC in the treatment of keloids, HS, BCCs, and cutaneous metastases.