Cancer is a hyper-proliferative disorder, which induces deformation of a natural cell by genetic mutations in DNA. Due to the high death rate associated with cancer, it is a major health problem for developing countries. Chemotherapy, Radiotherapy, and Chemically derived drugs are used in the treatment of tumors, however, researchers are finding out alternate methods for chemotherapy and radiation therapy. Ginger is a medicinal plant and is used as an anti-viral, anti-fungal, anti parasitic, antioxidant, and antibacterial agent. It possesses anticancer properties also. Most of the ginger ligands showed good interaction with the selected target but based on in silico analysis ADME (Absorption, Distribution, Metabolism, and Distribution) 6- gingerol was found superior due to its solubility and neurotoxic effect in comparison to the other compounds. The cytotoxicity of ginger increased with the increment of the concentration and its lower doses have preventive properties. The IC50 value recorded for both cancer cell lines after 22h treatment (Human Breast Cancer, colon Cancer) showed uniform cytotoxicity in both the cell lines studied. The study highlights the potential of 6-gingerol for drug development against cancer