Factors Influencing the Proliferation and Differentiation of Inner Ear Stem Cells - Abstract
Irreversible damage to cochlear hair cells is one of the main causes of sensorineural deafness. In recent years, it has been found that a class of cells with stem cell properties and the ability to differentiate into hair cells, which are called inner ear stem cells, and their proliferation and differentiation may be the ultimate solution of sensorineural deafness. Inner ear stem cells have the potential for selfrenewal and multi-differentiation, and their proliferation and differentiation processes are affected by a variety of factors, ranging from growth factors and miRNAs to the extracellular microenvironment and related signaling pathways, etc. This paper focuses on the factors affecting the proliferation and differentiation of inner ear stem cells.