Pheochromocytoma [PHEO] and Cushing syndrome [CS] may sometimes coexist and very rarely originate from the same adrenal gland. There were 12 cases in the literature in which corticomedullary involvement has been reported. A few cases of primary aldosteronism coexisting with Pheochromocy tomahave been reported so far. Also there is very little information about pheochromocytoma associated with Cushing’s syndrome. Cushing’s syndrome secondary to ectopic adrenocorticotropic hormone [ACTH] secretion has been frequently reported nowadays. Our literature search revealed no previous reports of a patient with PHEO and CS originating from the same adrenal gland and coexistent with acromegaly.