Introduction: Pneumonectomy presents an anatomical resection with a high rate of mortality and morbidity. This rate is still increased in the infectious affections such as destroyed lung. The serious complication after pneumonectomy remains bronchial fistula which requires an extended management. Methods: It was a retrospective study including all patients who had benefited of a pneumonectomy. The aim is to characterize clinical, paraclinical, and operative data. Results: Among 57 patients, there were 35 men and 22 women, with an average age of 42.6 years old. Respectively, pathological antecedents and clinical symptomatology were predominated by tuberculosis in 29 patients (50.8%) and the combination of haemoptysis with bronchorrhea in 23 patients (40.35%). imaging showed right-sided involvement in 28 patients (49.2%). The etiologies were predominated mainly by destroyed lung of tuberculosis origin in 34 patients (59.6%). Extrapericardial pneumonectomy was performed in 40 patients (70.1%), and intrapericardial in 15 patients (26.3%). 14 patients were presented a hemorrhage (24, 5%), postpneumonectomy empyema was recorded in 4 patients (7%), and death of 3 patients (5,2%). Long-term follow-up was 2 years without any marked recurrence. Conclusion: Pneumonectomy is accompanied with a high rate of mortality and morbidity. A well analysis of risk factors and good selection of patients allows decreasing this rate.