Application and Challenge of Metalloporphyrin Sensitizers in Noninvasive Dynamic Tumor Therapy - Abstract
Tumor treatment still face significant challenges. Though varies of treatment methods in clinic show certain therapeutic effects, serious side effects are often accompanied. Dynamic therapies, such as photodynamic therapy (PDT) and sonodynamic therapy (SDT), provide new opportunities for noninvasive tumor treatment. Sensitizers are crucial for dynamic therapy. Porphyrins and metalloporphyrins attract great attention due to their excellent photophysical properties and low cytotoxicity in dark. Metalloporphyrins shows greater potential for dynamic therapy because of the enhanced their photochemical and photophysical properties after metal ions coordinating to porphyrin rings. In this review, we introduced a comprehension on the mechanism of PDT and SDT, along with the recent progress in metalloporphyrins-based sensitizers against solid tumors. Additionally, the probable challenges and bottlenecks in clinical translation are also discussed.