A fast, simple and sensitive uric acid sensor was prepared by nano resin. The modi?ed electrode offers a considerable improvement in voltammetric sensitivity toward uric acid, compared to the bare electrode. Lewatit FO36 nano resin is a macroporous, mono dispersed, weakly basic, polystyrene-based resinwith graphite powderas new modi?ed carbon paste electrode (CPE/LFONR) was used for the electroanalytical determination of uric acid (UA) in real samples. The variation of peak current with pH and scan rate, were optimized. The electron transfer coef?cient and diffusion coef?cient of UA at the modi?ed electrode were calculated. The electrochemical behavior of UA at CPE/LFONR was studied by cyclic voltammetry (CV), linear sweep voltammetry (LSV), Chronoamperometry (CA) and Chronocoulometry (CC). Under the optimum conditions (pH and scan rate), a linear dependence of the uric acid oxidation signals was observed to concentration in the ranges of 0.3-3.1 µmol L-1 and 3.1- 32.0 µmol L-1 with a detection limit (3s) of 0.176 µmol L-1 at pH 6.0. Using chronoamperometry and Chronocoulometry, diffusion coef?cient was calculated 3.70 × 10-6 and 5.91 × 10-6 cm2/s respectively. The results indicate that the proposed method is highly sensitive for uric acid detection in real samples such as human urine and human blood serum.