Background: To optimize the absorbed radiation dose during a CT examination, manufacturers of CT Scanners have equipped their units with built-in softwares called Automatic Exposure Control (AEC). Purpose: Evaluate the knowledge of radiology technicians on the use of dose reduction software and the concept of patient radiation protection. Materials and methods: Descriptive and analytical transversal study from January 1 to December 1, 2020, conducted in the radiology and medical imaging services of Cameroon’s public and private hospitals with a CT-scanner. It was the first study on this topic that was conducted in Cameroon. This study was conducted from a questionnaire distributed to all medical imaging technicians in 10 hospitals relating to the notions of dose reduction software and patient radiation protection. Results: 80 questionnaires were distributed and analyzed. The average age of medical imaging technicians was 30 years old. There were 32 women and 48 men. Most of the medical imaging technicians worked in private centers (n = 6). 75% of medical imaging technicians had been in practice for more than 5 years. 75% of medical imaging technicians gave the wrong answer regarding the use of dose reduction software. Finally, only a third of the practitioners had received training in patient radiation protection. Conclusion: Although the majority of medical imaging technicians declares to take into account the dangers related to ionizing radiation during CT scan examinations, a radiation protection training, particularly during the initial curriculum are mandatory. The use and knowledge of dose reduction softwares from CT-scanners could be one of the solutions to reduce absorbed dose during a CT examination. So the importance of training technicians in handling of CT-scanners is beneficial.