Initial Biological Evaluations of [ 18F]KS-7-51 to Image PPAR-? in Tumor Mice Model - Abstract
Peroxisome proliferator-activated receptor gamma (PPAR-?) is a ligand-activated nuclear receptor transcription factor that plays a vital role in lipid regulation, antitumor, and anti-inflammatory responses. PET imaging of PPAR-? could provide critical information on tumor pathogenesis and treatment strategies. In this study, we report the radiochemistry and initial biological evaluations of [18F]KS-7-51, a p-fluoroethoxy phenyl derivative in a murine model of prostate cancer (PC3). In vitro cell uptake studies of [18F]KS-7-51 in PC3 cells showed high selectivity and specificity. Biodistribution in PC3-bearing mice demonstrated modest tumor uptake and blockade with KS-7-51 showed specificity. These results demonstrate the utility of [18F]KS-7-51 as a PPAR-? PET imaging agent.