Quality Control for Quantitative Evaluation of Cardiac Sympathetic Nerve Function with 123i-Metaiodobenzylguanidine - Abstract
Cardiac imaging with 123I-metaiodobenzylguanidine allows assessing cardiac sympathetic nerve function and aids the prediction of prognosis in heart failure and the differential diagnosis of neurodegenerative diseases. The heart-to-mediastinum (H/M) ratio is widely used as a quantitative indicator of cardiac accumulation; however, it is susceptible to the instrumentation, imaging parameters, and data-processing methods, and quality control is essential. This article briefly discusses technical considerations,
including collimator choice, correction methods, energy window settings, and selection of regions of interest, for reliable evaluation of cardiac accumulation of 123I-metaiodobenzylguanidine.