Staff organ doses were assessed and cancer risk were estimated for varying x-ray tube angulation in a cath-lab room at the emergency department of a hospital. Themoluminescence dosimeters (TLD) were used for the staff’s eye lens, thyroid, chest and gonad dosimetry. A fabricated wood and Perspex phantom were used to represent the staff and the patient respectively. The chest (cardiologist – 0.08 mSv), thyroid (nurse – 0.13 mSv), thyroid (cardiologist – 3.26 mSv) received the highest doses comparatively at AP 0o , LAO 45o and RAO 45o x-ray tube angulation respectively. Generally, the radiation dose to the staff was high for x-ray tube angulation of right anterior oblique (RAO) 45o . The thyroid organ recorded the highest cancer incidence risk comparatively for anterior posterior (AP) 0o , left anterior oblique (LAO) 45o and RAO 45o x-ray tube angulation, and for both sexes. However, generally, the cancer incidence risk estimates for females were higher than that of the males by a maximum factor of 3.2. The highest cancer risk incidence was 342.30 per 105 and 172.78 per 105 for female and male population respectively exposed in the thyroid organ. It is therefore recommended that staff doses should be optimised by using protective equipment (i.e. lead thyroid shield) to enhance staff protection.