The Connection between SRS Apparatus and Outcome in Patients with Brain Metastases from Lung and Renal Cancer - Abstract
Objective: Stereotactic radiosurgery (SRS) is an innovative approach for cancer therapy. It is thought to be generally a good choice even to radioresistent brain metastases (BM), taking also into consideration all of the prognostic factors and co-morbidities. But until now, it has not been revealed whether the apparatus is linked to the outcome. Methods: Because of that, the authors searched the published data on the world search engine for the last decades (1947-2017) on the subject of renal and lung cancer brain metastases (BM) and their radosurgical therapy, in regard to the used apparatus. Results: After processing the published data, the authors revealed that the three kinds of machines are leading to different results, concerning the brain metastases. LINAC and CyberKnife seem to be linked to the outcome, mainly to the local control/local failure, while GK’s analysis revealed no actual connection. Overall survival in general could be linked also to the machine, but it depends on many factors and such relation is difficult to be clearly determined. Conclusion: Concluding to this, it becomes clear that GammaKnife, CyberKnife and LINAC are not the same for the therapy of BM from primary lung and renal cancer. And before proceeding with SRS, it should be considered which machine would be used for the therapy, in order for a better outcome to be achieved.