Metabolic Dysfunction in Patients with Obstructive Sleep ApneaHypopnea Syndrome - Abstract
Obstructive Sleep Apnoea-Hyponea Syndrome (OSAHS) is a highly prevalent condition often associated with central obesity. In the past few years, several studies have analysed the potential independent contribution of OSAHS to the pathogenesis of metabolic abnormalities.
Objective: To analyze the metabolic dysfunction due to OSAHS independent of obesity.
Methods: It is a cross-sectional study of 48 adults (23 OSAHS and 25 controls). Anthropometric data (height, weight, and Body Mass Index (BMI)) were collected. All adults underwent the polysomnography measurement of apnea-hypopnea index (AHI) and the fraction of exhaled nitric oxide (FeNO) was measured.
Results: The presence of a metabolic syndrome and specifically of hyperglycemia has been widely described in patients with OSAHS. An increase in the exhaled fraction of NO in carriers of OSAHS was found, which may reflect a more pronounced bronchial inflammation in apneics compared to obese non-apneic patients.
Conclusion: Obesity explains the metabolic disorders in patients with OSAHS and the bronchial inflammation is related to OSAHS independent of obesity.: