Decellularized Tracheal Allograft in Micro-Miniature Pig: One Year Observation - Abstract
Purpose: Tracheal restoration is an essential treatment for tracheal congenital abnormalities, cancer or injury. We explored the potential of decellularized trachea to restore the trachea in swine, aiming on pediatric application. Method: We compared pigs with the allogeneic decellularized tracheal graft patch and those with the autotransplanted tracheal patch. Result: Distortion of the tracheal lumen was observed in both cases. No respiratory symptoms appeared during observation. Histologically, the foci of cartilage regeneration from the recipient trachea was demonstrated in the specimens, suggesting the induction of tracheal reconstitution. Conclusion: Allogeneic decellularized tracheal grafts could serve as a feasible tracheal restoration, especially for pediatric patients.