Mortality rates for neutropenic patients with peri-anal sepsis are high, but there is no consensus in the literature as to the optimal management strategy. At Leicester Royal Infirmary, UK, we have adopted a multidisciplinary approach as standard, with broad-spectrum antibiotics, peri-anal examination with debridement if necessary, and routine defunctioning colostomy. Eleven patients were treated according to this protocol between January 2001 and December 2015, with 9/11 full recovery from the sepsis and the procedure, and 5 subsequently having colostomy reversal. In an area of relatively scant evidence, we conclude that these patients should not be denied a surgical procedure.