Buschke Lowenstein tumor (BLT) or giant condyloma acuminatum (GCA) is a sexually transmitted disease, of viral origin, essentially due to the human papillomavirus. BLT is relatively common in males and occurs in 81-94% of cases in the penis and in 10-17% of cases in the anorectal region. Risk factors include poor hygiene, immunosuppression, smoking and STIs. It is characterized by a more or less ulcerated budding lesion of the genital or perianal region, and the evolution is slow and can be associated with several complications including superinfection, fistulization to neighboring organs, necrosis, or hemorrhage. A wide radical excision, followed by reconstructive surgery, seems to be the optimal therapeutic strategy for BLT management, however other treatments have been proposed in order to try to reduce the tumor and to limit surgical damage.