Introduction: Prostate cancer is one of the most common cancer in men and increases with the aging. Having 87.6% of the deaths occurred in the population over 65 years of age. Nevertheless, many aspects remain unclear or controversial. Materials and methods: Observational, analytical and transversal study. Men older than 60 years with prostate cancer diagnosed for the first time in the service of Urology in the General Hospital of Zone 50 SLP Mexico with a total sample of 50 patients, were it was taken the determination of FSH, LH, PSA and PRL. The statistical tests used with P ?0.05were Mean, Standard Deviation, Analytical Student T and Pearson correlation. Results: In our study population in patients with prostate cancer with a mean age of 72 years there were no differences in the levels of PSA, PRL, LH, FSH in both groups. However, we found a slightly greater difference in the over 80s. Which we believe is due to the physiopathology of the testicular deficiency. Conclusion: Serum hormones determined in this study LH, FSH and PRL were not found to influence prostate specific antigen levels in elderly patients with prostate cancer, although PSA levels were not associated with prolactin levels. This finding allows you to know that there is no direct relationship of PRL and PSA.