Novel Case of Eosinophilic Solid and Cystic Renal Cell Carcinoma in a Pediatric Male - Abstract
Introduction: Eosinophilic Solid and Cystic Renal Cell Carcinoma (ESC RCC) is a recently described morphologic subgroup of renal cell carcinoma (RCC). It was originally classified in patients with Tuberous Sclerosis Complex (TSC) but has since been seen to occur sporadically. The median age has been reported from 27 to 57 years with a roughly 13:1 female predominance. (1) The occurrence of this tumor subtype in a young adolescent male is highly unusual and rare. We present a case of ESC RCC arising as a single, incidentally discovered renal mass in a 17-year-old male. Discussion: We present a novel case of ESC RCC in a pediatric male. Only three incidences of ESC RCC in the pediatric population have been documented prior to our case report, with only one occurring in a male. Compared to previous pediatric cases which featured multifocal lesions and one case of metastasis, our patient had a solitary, organ confined mass. Our patient’s tumor was identified as ESC RCC by reviewing the gross appearance of the mass and immunohistochemistry, most notably showing CK20 positivity which is uncommon in other RCC subtypes. At this juncture, ESC RCC is an emerging entity and is not formally recognized by the 2016 WHO classification of genitourinary tumors. However, it is our hope with this report to contribute to the further characterization of ESC RCC as a novel entity.