Penile calciphylaxis, a rare occurrence of calcific uremic arteriolopathy, is not frequently addressed in the literature. Conservative and surgical management have been found to have similar outcomes regarding mean survival time, leading to controversy around the advantages of surgery for this illness. This report showcases an ESRD patient dependent on hemodialysis who experienced severe penile calciphylaxis that made conservative treatment unfeasible. The case required immediate intervention through penectomy as a means of stopping disease advancement and enhancing quality of life for the patient.