Objective: To derive the risk factors affecting the perioperative period of urologic stones complicating urogenital sepsis through systematic evaluation. Methods: A computerized search of the literature on perioperative risk factors associated with urologic stones complicating urosepsis was performed in PubMed, Embase, Web of Science, The Cochrane Library, CNKI, Wanfang, and other databases. The search timeframe was from database construction to June 2024. Meta-analysis was performed using RevMan 5.4 and Stata 15 software. Results: A total of 42 papers were included, in which age ?60 years [OR = 1.95, 95% CI (1.55, 2.50)], Female [OR = 1.28, 95% CI (1.17, 1.40)], Positive urine culture [OR = 1.77, 95% CI (1.38, 2.28), Intraoperative irrigation volume >20 L [OR = 4.89, 95% CI (3.69, 6.49)], Stone diameter >20 mm [OR = 1.59, 95% CI (1.35, 1.88)], Positive procalcitonin (PCT) [OR = 1.76, 95% CI (1.29, 2.41)], Urinary tract infection [OR = 4.02, 95% CI (1.92, 8.41)], Diabetes mellitus [OR = 1.82, 95% CI (1.53, 2.17)], Percutaneous nephrostomy tract size >20F [OR = 6.18, 95% CI (33.26, 9.63)], Urinary nitrite positivity [OR = 2.20, 95% CI (1.04, 4.67)], Operative time ?90 minutes [OR = 1.13, 95% CI (1.03, 1.23)], Multiple stones [OR = 6.89, 95% CI (3.24, 14.64)], Preoperative antibiotic non-use [OR = 2.97, 95% CI (1.41, 6.26)], Fever [OR = 3.62, 95% CI (2.11, 6.21)], Obesity [OR = 2.44, 95% CI (1.36, 4.38)], were the risk factors for urologic stones complicating urogenital sepsis. toxemia perioperative related risk factors. Conclusions: Age ? 60 years, female, obesity, diabetes mellitus, fever, urinary tract infection, positive urine culture, urinary nitrate, calcitoninogen, no preoperative antibiotics, intraoperative irrigation fluid usage >20 L, percutaneous renal access >20 F, surgery time ?90 minutes, stone diameter ? 20 mm, and multiple stones significantly increased the risk of urinary stones complicating urogenic septicemia, providing healthcare profes