A Mixture of ?, ?-amyrin Causes Anxiolytic, Sedative, and Anticonvulsant Behavior without Impairing Memory in Adult Zebrafish - Abstract
The isomeric mixture of ?- and ?-amyrin isolated from Protium heptaphyllum has considerable pharmacological effects, mainly with an effect on the central nervous system. Still, no reports in the literature demonstrate its impact on zebrafish. This study evaluated the anxiolytic, sedative, anticonvulsant and memory effects of the isomeric mixture of ?- and ?-amyrin (ABAM) isolated from Protium heptaphyllum. ABAM was submitted to light-dark tests, seizures induced by pentylenetetrazol and inhibitory avoidance induced by electroshock in adult zebrafish. ABAM showed sedative, anxiolytic and anticonvulsant effects,preventing memory in adult zebrafish via GABAergic neurotransmission. However, ABAM has pharmacological potential for the treatment of anxiety and seizures while preserving memory, which can be explained by an interaction with the GABAA receptor.