A Promising Modality of Oncolytic Virotherapy for Cancer Treatment - Abstract
Tumors are complex entities that continue to challenge modern medicine to develop more effective cancer therapies. Oncolytic virotherapy is a relatively new and thriving field of therapy targeted towards curing cancer by using the infamous viruses to selectively infect and kill tumor cells. Better resistance and specificity to tumor cells as well as their multiple mechanisms of cytotoxicity compared to contemporary means of 9oncotherapy present oncolytic virotherapy as a fascinating and viable field of scientific inquisition in the persistence battle with cancer. Even though it is state of the art in cancer therapy, virotherapy has some fall shorts. This include activation of the immune system to oncolytic viruses, inability to remove all metastatic cells, demands of combination therapy for real efficacy and, lack of cell culture and animal tumor models that accurately reflect
the characteristics of cancerous tissues in human patients. To overcome these constraints, detailed understanding about manipulation of: the viral genetic makeup, biology of abnormally growing tumor cells and the complex system of the host’s natural immune response mechanisms for their tumor selectivity and mechanisms of action is necessary.