Age-Dependent Change of Hepatic Flavin Containing Monooxygenase and Aldehyde Oxidase Activities in Chickens - Abstract
Flavin containing monooxygenases (FMO) and aldehyde oxidases (AO) are two important groups of non-cytochrome P450 enzymes in animals and humans. Age-dependent hepatic activities of those enzymes were evaluated in male Ross 708 broiler chickensat age 1, 7, 14, 28 and 56 days. FMO activity was significantly higher in chicken livers at age of day 1, declined rapidly to the lowest level measured at age of day 14 and then gradually increased. Mean-while hepatic AO was low in chicken at age of day 1 and gradually increased. The overall AO activity in chicken liver was low compared to its hepatic FMO or CYP450 reported previously. Since FMO and AO activities are age-dependent in chicken livers, the impact of age on endogenous and exogenous metabolism by hepatic FMO and AO should be considered.