Assessment of the Profile of Enzymatic Changes in Sick Dogs with Heart Disease in Iran - Abstract
In a recurrence, the levels of superoxide dismutase enzymes (SOD), lactate dehydrogenase (LDH) glutamate pyruvate transaminase (GPT), the levels of hemoglobin (HB) and hematocrit (PCV) were measured) in 20 healthy dogs and 30 dogs with heart disease (control).
The mean SOD values between healthy and diseased dogs showed a significant difference. SOD concentration was significantly decreased in sick dogs as compared to healthy dogs. Whereas, LDH, GOT and GPT enzymes concentration were significantly increased in dogs with heart failure as compared with the control. However, the mean values of HB and PCV showed no significant differences between the groups of dogs. There was also a significant correlation between SOD, age and PCV value in diseased dogs.
In healthy dogs, there was no significant correlation between SOP values and other factors. The deficiency of the SOD enzyme over time generates free radicals such as free O2 molecules and reduces the neutralization of these free radicals resulting in the damage to the specific organ such as heart and causing heart disease.