A cross sectional study was conducted from November 2018 to June 2019 in apparently healthy sheep at Haramaya manucipal abattoir to estimate the prevalence, cyst distribution and economic loss of Cysticercustenuicollis in Slaughtered sheep. Ante-mortem inspection was carried out on arrival in the lairage; temporal identification numbers were given for individual animals were recorded. Then after, post-mortem examination was performed in each organ and carcass of individual animals along their identification number to detect gross abnormalities and aesthetic reasons that rendered each organ to be rejected from local market. During the study, a total of 384 sheep were randomly sampled and examined postmortem after slaughter for presence of C. tenuicollisin the visceral organs of the animals using standard meat inspection procedures and laboratory result. The collected data and stored into Microsoft excel was analyzed using SPSS.ver.20 (USA) statistical software. Out of the 384 sheep inspected for visceral organs, C. tenuicolliswas found in of 89 (23.2%) sheep. Adult sheep 87 (24.6%) were more infested than young 2(6.5%) with statistically significant difference (p=0.021). Sheep with poor body condition 21 (34.4%) were found most infected compared to medium 47 (24.5%) and good 21 (16%) body condition with statistically significant difference (p=0.016). More infected sheep were found in kersa 50 (41%), Aweday 25 (20%) and haramaya 14 (10.2%). This study also shows that C. tenuicollisis more frequently detected in the liver 40 (10.4%) of sheep than any other visceral organs and the peritoneum was the least 9 (2.3%). The liver lesions are unsightly and affect the texture of the tissue, making it unsuitable for human consumption and as a result extensive financial loss associated with condemnation of liver occurred. The annual loss due to the rejection of liver from the sheep slaughtered in the Haramaya municipal abattoir was estimated approximately 77,220.8 ETB. So as to reduce these losses, further comprehensive studies that include all the representative export and local slaughter houses should be done as to introduce appropriate preventive and control strategies that avoid the unnecessary financial losses.