This article aims to explain how in my research laboratory, it was possible to transform 2 behavioral anxiety tests: elevated plus maze and four-plate test, into more efficient tests that make it possible to take into account in human clinic the phenomenon of tolerance. This well-known phenomenon for benzodiazepines can be studied for potential new anxiolytic molecules. This also allowed us to begin to study aversive memory which seems important in demonstrating an anxiolytic action in animal models of anxiety