The Significance of Triclabendazole Resistance - Abstract
Triclabendazole is the best fasciolicide available with activity against very young fluke. But
there are increasing numbers of reports of resistance including failure of therapy in humans.
Determining the resistance status on ‘fluky’ farms is essential as high mortality of sheep can occur if it is not realised resistance is present. The options for control are confined to other less effective products and failure of closantel as well could lead to the closure of some sheep farms in the UK. Preventing fluke infections though pasture management is difficult or may be impossible so development of a vaccine is urgently required.