Objective: The present study aims to address the association of COVID-19 vaccines on the menstrual cycle among reproductive women in Jeddah, Saudi Arabia, 2022. Methods: This is a cross sectional study that was carried out in Jeddah, Saudi Arabia which included a total of 676 female individuals of reproductive age. Data was collected through questionnaire that was distributed and filled out by the participants, which then were analyzed using SPSS.Results: Approximately 52% of all 676 total number of participants, reported having their menstrual cycle affected and having some disturbances that were not present prior to receiving COVID-19 vaccines, knowing that more than 80% of all participants had already received three doses of COVID-19 vaccine. The most common reported menstrual abnormalities in the present study were irregular menses (16%) followed by dysmenorrhea (14%), Conclusion: COVID-19 had major effects on our lives that required the development of a vaccine against it, however it had some side effects associated with it, such as causing changes in the menstrual cycle in form of getting more irregular, having more pain or bleeding, or having the cycle get shorter or longer.