Adult idiopathic thrombocytopenic purpura (ITP) is an acquired organ-specific autoimmune disorder characterized by accelerated platelet destruction. This is due to the production of autoantibodies against platelets membrane glycoproteins which results in the destruction of platelets via the reticuloendothelial system. It can be also caused by platelet production problems. The primary immunologic defect in ITP is having autoreactive B-lymphocytes secreting antiplatelet antibodies. The dysfunctional cellular immunity is also very important in the pathophysiology of ITP