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    Volume 1, Issue 1
    Original Research Article
    Jiao Meng, Zhenyu Lv, Xiaopeng Li, Chuanxin Sun, Zhengguo Jiang, Wanchang Zhang, Chang Chen*
    Lycium barbarum, a classic Chinese medicine, has a large variety of biological activities, including improvements in immunity, as well as anti-aging and anti-oxidation activities. It has been used to improve or restore deteriorating functions related to aging and diseases. Although its nerve protection effects also have been proved in vitro and in vivo, the molecular mechanism of action is not clear. Here, we report on the effect and possible mechanisms of Lycium extract-mediated protection of Ab-induced paralysis in Caenorhabditis elegans. Lycium extracts effectively reduced Ab accumulation and delayed Ab-induced paralysis in a transgenic C. elegans (CL2006) model that expresses human Ab1–42. By evaluating the expression of genes related to the proteostasis network, we found that the expression of UPRmt, UPRER and autophagy-related genes was induced by Lycium extracts in CL2006 transgenic strains but not in the wild-type stains. Further RNAi experiments demonstrated that knock down of the UPRmt-related genes could reduce levels of down-regulation induced by Lycium extracts, suggesting that UPRmt is necessary for Lycium to prevent Ab aggregation and maintain protein stabilization. Therefore, our studies provide more insights into the action and molecular mechanism of Lycium barbarum as a potential neuroprotective agent.
    Original Research Article
    Vladimir Zaichick*, Sofia Zaichick
    A prevalence of thyroid dysfunction is higher in the elderly as compared to the younger population. An excess or deficiency of chemical element contents in thyroid may play important role in goitro- and carcinogenesis of gland. The variation with age of the mass fraction of eight chemical elements (Br, Ca, Cl, I, K, Mg, Mn, and Na) in intact (normal) thyroid of 72 males (mean age 37.8 years, range 2-80 years) was investigated by instrumental neutron activation analysis with high resolution spectrometry of short-lived radionuclides. Mean values and standard error of mean for mass fractions (mg/kg, on dry-mass basis) of the chemical elements studied were: Br 13.7±1.0, Ca 1703±131, Cl 3449±219, I 1786±940, K 6289±329, Mg 306±19, Mn 1.31±0.07, and Na 6820±214. This work revealed that there is a statistically significant increase in Ca and I mass fraction, as well as a decrease in K and Mn mass fraction in the normal thyroid of male during a lifespan. Moreover, a disturbance of intrathyroidal chemical element relationships with increasing age was found. Therefore, a goitrogenic and carcinogenic effect of inadequate Ca, I, K, and Mn level in the thyroid of old males and a harmful impact of disturbance in intrathyroidal chemical element relationships with increasing age may be assumed.

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