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    Volume 2, Issue 1
    Case Report
    Alessia Mingarelli, Francesca Manzoni, Paola Olgiati, Maria Paola Canevini, Aglaia Vignoli*, and Elena Zambrelli
    Autism Spectrum Disorders (ASDs) are neurodevelopment disorders characterized by persistent impairments in reciprocal social interaction and communication, restricted interests, and stereotypical behaviors. Sleep problems in ASD are a prominent feature, many of which are often unrecognized. Psychiatric and psychotic morbidities can coexist, making differential diagnosis challenging between an exacerbation of pre-existing symptoms and an organic pathology of new onset.
    We describe the case of a 6 years old girl with high functioning ASD presenting new onset of subacute psychotic symptoms (vivid terrific visual hallucinations) and sleep disturbance (difficulty at falling asleep, frequent awakenings). Polysomnography (PSG) detected periodic legs movements during sleep (PLMs – Index 11), persisting during REM sleep, with dystonic features. A slight positivity detection of Anti-GAD Antibodies in serum and CSF was detected. Symptoms improved after corticosteroids and intravenous immunoglobulin treatment.
    Maria Arvio*, Timo Nyrke, Markus Müller, and Nina Bjelogrlic-Laakso
    In this paper, we describe a 42-year old woman with intellectual disability of unknown origin, epilepsy and treatment resistant neuropsychiatric symptoms, who was bed-ridden for decades until the identification of the underlying genetic syndrome, Angelman syndrome, as well as the recognition of the specific epilepsy syndrome, myoclonic status in non-progressive syndrome, and the initiation of an orphan antiepileptic drug, stiripentol, with good response.
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