Aortic Arch Baroreceptor Stimulation: A Novel Method to Lower Blood Pressure - Abstract
Rationale: Hypertension is a common cardiovascular risk factor and is treated with pharmacological and non-pharmacological means. An aortic baroreceptor stimulation device based strategy has been tested for the manipulation of blood pressure in an experimental goat model. No prior clinical trials exist in this field. Twenty one experimental animals were used in this study. Long term effects of this procedure are unknown. No primate or human experiments have been conducted. This may be a novel therapy for the treatment of hypertension. Objective: The study assessed the effect of aortic baroreceptor activation therapy on manipulation of systolic blood pressure. Methods and Results: Twenty one experimental goat animals Capra aegagrushircus ranging from age 6 months to two years were enrolled in this cohort study. The study was conducted with intention to treat. This study was done as proof of concept/principle for manipulation of blood pressure and to assess whether the Octad stimulation system will result in significant blood pressure lowering. Baseline blood pressure was a median of 111.8 mmHg with interquartile range of 16.8. After stimulation the median blood pressure was 88 mmHg with interquartile range of 21.0. The average lowering in blood pressure was 22.4 mmHg. Conclusion: The results of this pilot study support the role of aortic baroreceptor stimulation to achieve significant blood pressure lowering. There might be an emerging role for development of a stimulation device for the treatment for high blood pressure. Aortic baroreceptor stimulation needs further investigation. First to be investigated would be the effect on diastolic blood pressure and mean arterial pressure. The second area that needs to be evaluated will be a cross species effect.