A Review on Anticancer and Antimicrobial Activity of Tetrafluoroquinolone Compounds - Abstract
The prokaryotic type II topoisomerases (DNA gyrase and topoisomerase IV) and the eukaryotic type II topoisomerases represent the cellular targets for quinolone antibacterial agents and a wide variety of anticancer drugs, respectively. In view of the mechanistic similarities and sequence homologies exhibited by the two enzymes, tentative efforts to selectively shift from an antibacterial to an antitumoral activity was made by a series of functionalized teracyclic fluoroquinolones. Thus, as part of a continuing search for potential anticancer drug candidates in the quinolones series, the interest in cytotoxicity of functionalized tetracyclic fluoroquinolones. The growth inhibitory activities of tetracyclic fluoroquinolones were against cancer cell lines using an in vitro cell culture system. Some of tetracyclic fluoroquinolones showed in vitro cytotoxic activity. The tetracyclic group of fluoroquinolones series changes the biological profile of quinolones from antibacterial to cytotoxic activity. The tetracyclic fluoroquinolones have excellent potential as a new class of cytotoxic agents.