Families of chronic mentally ill person experience a perception of burden due to the loss of ability that occurs in their patients. Burden is the negative effect on the caregiver. Objective burden refers to the negative outcomes in family routines and subjective burden refers to the emotional distress experienced by the caregiver. Perception of burden and difficulties of giving care may cause impairment of physical and mental health in caregivers. In this review two different intervention programs will be introduced to help reduce the burden of caregivers perceive the chronic psychiatric patients. The first of these is “Caregiver Empowerment Program” and the other one is “Family to Family Support Program”.