Patient Navigation was introduced over two decades ago as a patient-centered approach for identifying individuals most at risk for delays in care, and mitigating barriers to their receipt of care. Patient Navigators provide the logistical and emotional support for completion of discrete episodes of health or illness care. Patient Navigators guide patients through healthcare system complexities, while providing motivational influence for positive behaviors, ensuring that care is as efficient and as seamless as possible. There is significant potential to expand the use of Patient Navigation to assist high-risk patients in achieving adherence to either preventive care or treatment guidelines. Nurses are uniquely suited to excel in Patient Navigation roles. Nurses are trusted professionals who have a presence throughout the healthcare system and are therefore well-positioned to identify, educate and engage high-risk patients or families when they present at healthcare access points, and guide them through completion of a health care episode. Our article discusses potential opportunities to introduce Patient Navigation competencies into undergraduate nursing education curriculum