Theoretical framework plays an essential role in guiding advanced nursing practices. The theoretical foundation of nursing discipline is based on various grand and middle range theories. Despite of progressive change in nursing knowledge and care; nightingale model of care is still the basis of all nursing practice. This paper aims to discuss the implications of nightingale theory in clinical setting through a clinical scenario. It will discuss the significance of 13 canons of nightingale theory with the significance in todays advanced care. Nightingale’s theory is purely applicable in clinical setting and it guides health care professional to increase patient’s wellbeing and restore health by making alteration in the surrounding.