Heparin-Derived Oligosaccharides Inhibit VEGFInduced Angiogenesis In vitro - Abstract
Abstract
Anti-angiogenesis treatment of tumors has become a potential anti-tumor treatment option. We found that HDO can significantly inhibit the proliferation, migration, and adhesion of HUVEC cells, and has anti-angiogenic activity. One of its mechanisms of action is to affect the formation of the VEGF/VEGFR complex by downregulating the transcription and expression of VEGFR-2, thereby regulating the activation of downstream signaling pathways.