Dengue and Leptospira CoInfection - Abstract
Dengue and Leptospira not only share ecological niches, but also manifest with similar clinical presentation. Serologic evidence shows that co-infection by both pathogens is not uncommon in endemic areas. After performing a systematic search, we have here reviewed and analyzed a series of case reports on dengueLeptospira coinfection from around the world.
We observed a positive correlation between bilirubin with hematocrit, and a negative correlation between platelets and hematocrit, and platelets and pulse, as well as between fever and creatinine, during co-infection. Mortality was a variable accounting for data clustering. Differences in age may also play a role in the mortality of co-infection with leptospirosis and dengue
A physician’s consideration of the possibility of co-infection, and knowledge of the clinical presentation of when both infections are present, may allow for a rapid diagnosis and an adequate treatment plan that may reduce mortality.