We report four women with seropositive Rheumatoid Arthritis (RA) presenting with concomitant Desquamative Inflammatory Vaginitis (DIV). No convincing evidence emerged establishing a causal connection between RA and DIV, or indicating that DIV was an extra- articular manifestation of RA. Similarly, use of rituximab was not shown to be a causal factor in pathogenesis of vaginitis.