Lymphogranuloma Venereum with Bilateral Bubo: A Case Report - Abstract
Lymphogranuloma Venereum (LGV) is a sexually transmitted infection caused by the invasive intracellular bacteria Chlamydia trachomatis serovars L1–L3. LGV is distributed worldwide and most prevalent in the tropics and subtropics, but also causes outbreaks in developed countries within risk groups. LGV causes a systemic disease and most commonly begins with transient, painless genital papules or ulcers, and later on leads to excessive regional lymphadenopathy. In men having sex with men (MSM), this presentation is uncommon, and colitis or proctocolitis is the predominant sign of infection. Diagnosis is based on a combination of clinical presentation, epidemiologic findings, and Nucleic Acid Amplification Techniques (NAAT). Treatment of choice is doxycycline 100 mg or 200 mg once daily for 21 days. We report a case of lymphogranuloma venereum in an HIV-positive patient who had bilateral inguinal involvement, a very uncommon occurrence, associated with cutaneous lesions of molluscum contagiosum. He underwent therapy with doxycycline 100 mg/day for 30 days, showing a significant reduction in the inguinal buboes, but died as a result of cerebral cryptococcosis.