Effects of Exercise in Obesity-Induced Low-Grade Inflammation - Abstract
Adipose tissue was for a long time seen as just a way of storing excess of energy. However, in the second half of the past century many studies began to show that adipose tissue is in fact an endocrine organ with autocrine and paracrine functions due to the secretion of biologically active molecules, collectively called adipokines. The fast mass expansion caused by hypertrophy in obesity makes some regions of the adipocytes distant to the blood
vasculature, thus leading to low PO2. Hypoxia underpins the initiation and progression of
the inflammatory response that includes increase in the production of tumor necrosis factor alpha (TNF-?), Interleukin-6 (IL-6) and leptin and reduction in the production of adiponectin.
Exercise effects had been seen as indirect but new evidence suggests that exercise has
somatory effects to diet and is more effective when weight loss is the same. No specific type
of exercise shows to be superior in improving inflammatory profile in obesity.