Intermediate and Very Low Density Lipid Particle Sizes are Important in the Clinical Manifestation of Younger Patients with Acute Coronary Syndromes - Abstract
Acute coronary syndrome (ACS) refers to a spectrum of clinical presentations associated with rupture of an atherosclerotic plaque and partial or complete thrombosis of the infarct - related artery.
Aim of the study was to estimate the whole lipid spectrum particles among patients in the acute phase of myocardial infarction (acute coronary syndrome in younger age - in their fourties). Lipid particle size of IDL and VLDL lipoproteins in the pathology among acute coronary syndrome younger patients have not been estimated yet.
In a group of consecutive 60 patients suffering from acute coronary syndrome serum lipid particles have been bed -side measured with FDA approved method Lipoprint Quantimetrix system. Lipid subfrections of LDL, IDL, VLDL and HDL - cholesterol have been measured with gradient polyacryamid gel electrophoresis at time of the event comparing to the controls. The subfraction - analysis allowed the examination of the cardiovascular risk beyond the common blood cholesterol testing.
The result showed, that lipid subpopulations under pathological state gives evidence of characteristic shift toward small LDL as well as small HDL particles among acute coronary syndrome patients. Together with VLDL and IDL lipoproteins are counting to their impaired outcome, thus carrying the certain significant atherogenic potential they contribute to their worse outcome risk.