Introduction: Major lower limb amputations are common procedures performed in elective and emergency settings, with diabetes mellitus and peripheral vascular disease as the main causes. There is a strong financial impact on the health system and a notorious psychosocial impact on patients. Objective: To describe the statistical behavior of hospitalizations due to major lower limb amputations, as well as their distribution in Brazilian regions. Materials and Methods: A descriptive, observational, retrospective study based on secondary data extracted from the SUS Hospital Admissions System (SIH/SUS) between 2008 and 2023. Results: 371,232 hospitalizations were recorded, with an increase in the number of hospitalizations of 67.03%. The Southeast and Northeast regions accounted for the largest absolute numbers, with 42.12% and 32.52% of hospitalizations, respectively. The Northeast had the highest average hospitalization rate (12.9). There were 47,264 deaths and an average mortality rate of 12.73 in Brazil. Conclusion: There was a greater concentration of the number of procedures, especially in the Southeast and Northeast, reflecting regional population disparities. In addition, the relative growth rate in the number of amputations is especially noticeable in the North and Center-West, possibly related to the growth and aging of the population.