Development of Various Processing Strategies for New Generation Antibiotics Using Different Modes of Bioreactors - Abstract
Bioreactor design is an integral part of bioprocess intensification. The sole aim of process design is to identify the thrust areas and improve the production of the desired metabolite. Complex secondary metabolites like antibiotics are of great importance. Several researchers have highlighted the significance of media formulation, feed strategies, and control of physico-chemical parameters, metabolic engineering and genetic improvement for enhanced antibiotic fermentation. But, there is a lacuna regarding various aspects of bioreactor design and analysis for antibiotic fermentation. In this short communication, we have summarized our research work/ findings on improved antibiotic production through strategic design and development of bioreactors as a case study. The physical design and operational conditions can significantly tackle problems of substrate inhibition, poor cell growth and improper oxygen mass transfer. Thus, helping in meliorated production of several life-saving drugs.